When female mosquitoes are looking for a human to bite, they smell a unique cocktail of body odours that we emit into the air.
These odours then stimulate receptors in the mosquitoes’ antenna.
Scientists have tried deleting these receptors in attempts to make humans undetectable to mosquitoes.
However, even after knocking out an entire family of odour-sensing receptors from the mosquito genome, mosquitoes still find a way to bite us.
Now, a group of researchers, publishing in the journal Cell on Aug 18, found that mosquitoes have evolved redundant fail-safes in their olfactory system that make sure they can always smell our scents.
“Mosquitoes are breaking all of our favourite rules of how animals smell things,” said Margo Herre, a scientist at Rockefeller University and one of the lead authors of the paper.
In most animals, an olfactory neuron is only responsible for detecting one type of odour.
“If you are a human and you lose a single odourant receptor, all of the neurons that express that receptor will lose the ability to smell that smell,” said Leslie Vosshall of the Howard Hughes Medical Institute and a professor at Rockefeller University and the senior author of the paper.
“But she and her colleagues found that this is not the case in mosquitoes.
“You need to work harder to break mosquitoes because getting rid of a single receptor has no effect.
“Any future attempts to control mosquitoes by repellents or anything else has to take into account how unbreakable their attraction is to us.”
“This project really started unexpectedly when we were looking at how human odour was encoded in the mosquito brain,” said Meg Younger, a professor at Boston University and one of the lead authors of the paper.
They found that neurons stimulated by the human odour 1-octen-3-ol are also stimulated by amines, another type of chemical mosquitoes use to look for humans.